Table 1.

Topics discussed in the lecture sessions in experiments 1 and 2

Topics Discussed
Lecture on resting membrane potential
  • Composition of the intracellular and extracellular environments.

  • Diffusion of substances through permeable and semipermeable membranes.

  • Permeability of the plasma membrane and its relationship to ion leak channels.

  • Differences in electrical charge generated by a selectively permeable membrane.

  • Equilibrium potential of an ion and the Nernst equation.

  • Difference in electrical charges through the plasma membrane.

  • Sodium (Na+) and potassium (K+) leak channels present in the plasma membrane.

  • Goodman-Hodgkin-Katz (GHK) equation.

  • Function of the Na+-K+-ATPase pump.

Lecture 1 on action potential
  • Dynamics of voltage-gated ion channels.

  • State of leak channels during phases of the action potential.

  • Difference between graded potentials and action potentials.

  • Graph of the action potential over time.

  • State of ion channels during different phases of the action potential.

Lecture 2 on action potential
  • Relative and absolute refractory periods.

  • Influence of changes in the ion concentrations in the extracellular environment on triggering action potentials.

  • Action potential mechanisms and drug development.