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Advan. Physiol. Edu. 33: 144-156, 2009; doi:10.1152/advan.90208.2008 Free Article
1043-4046/09 $8.00
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ADV PHYSIOL EDUC 33:144-156, 2009
© 2009 American Physiological Society

RESEARCH-ARTICLE

Standing on the shoulders of giants: Dean Franklin and his remarkable contributions to physiological measurements in animals

R. Dustan Sarazan and Karl T. R. Schweitz

Covance Laboratories Incorporated, Madison, Wisconsin

Address for reprint requests and other correspondence: R. D. Sarazan, Covance Laboratories Inc,, 3301 Kinsman Blvd., Madison, WI 53704-2523 (e-mail: Dusty.Sarazan{at}covance.com).

Abstract

The use of electronic instrumentation to monitor physiological function in conscious research animals and humans has become routine. Beyond basic research, animal studies using these methods are required by government regulatory agencies worldwide before human testing of potential new drugs. Living, as we do, in an age of miniaturized high-tech electronic devices, we are accustomed to believing this technology is easy; however, this has not always been the case. While a broad supporting cast of engineers, physiologists, fellows, and technicians was involved, the true innovators were Dr. Robert Rushmer, Dr. Robert Van Citters, and Mr. Dean Franklin. Before Dean Franklin's death in 2007, the primary author recorded ~5 h of interviews with him at his home in Columbia, MO. An additional approximate 1.5-h interview was recorded with Dr. Van Citters via telephone. The information contained herein is based on the recollections of these men as recorded in their interviews.

Key words: Doppler flowmeter; sonomicrometer; telemetry; implantable pressure transducer






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