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APS REFRESHER COURSE REPORT

CURRENT TOPICS FOR TEACHING SKELETAL MUSCLE PHYSIOLOGY

Department of Molecular and Integrative Physiology and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109

Abstract

Contractions of skeletal muscles provide the stability and power for all body movements. Consequently, any impairment in skeletal muscle function results in some degree of instability or immobility. Factors that influence skeletal muscle structure and function are therefore of great interest both scientifically and clinically. Injury, disease, and old age are among the factors that commonly contribute to impairment in skeletal muscle function. The goal of this article is to update current concepts of skeletal muscle physiology. Particular emphasis is placed on mechanisms of injury, repair, and adaptation in skeletal muscle as well as mechanisms underlying the declining skeletal muscle structure and function associated with aging. For additional materials please refer to the "Skeletal Muscle Physiology" presentation located on the American Physiological Society Archive of Teaching Resources Web site (http://www.apsarchive.org).

Key words: review; cross-bridge; contraction; atrophy; injury; aging